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Many recent studies showed serial measurement of serum albumin can even better predict chronic inflammation and clinical events (35-37). Looking at the results of all these studies it is clear that hypoalbuminemia is adversely associated with CVD in ESRD. Stenvinkel et al. (38) were first to demonstrate that patients in predialysis chronic renal failure with carotid plaque has lower serum albumin level. Nobuhiko et al demonstrated that even in predialytic phase of chronic renal failure buy clomid post cycle therapy hypoalbuminemia is an excellent reflection of CVD (39). Our study concludes that this is true even in patients with less severe kidney dysfunction. So serum albumin can be a helpful predictor of CVD at early stage of CKD and this patient population needs focused attention because early detection and intervention can provide better outcome.. 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Positive symptom severity in this study was assessed using the scale for the assessment of positive symptoms (SAPS) and negative symptom severity was assessed using the scale for the assessment of negative symptoms (SANS). In this study, we recruited 210 chronic schizophrenia patients with different onset ages and 122 healthy individuals to serve as controls (HC) between 20 and 65 years old. The patients with chronic schizophrenia met the following criteria: (1) onset of psychotic symptoms more than 24 months earlier; and (2) currently receiving antipsychotic medication treatment. The healthy controls met the criteria: (1) absence of a current or past psychiatric disorder as confirmed by DIGS-C. There were 84 patients with early-onset schizophrenia (EOS, onset age < 20), 126 patients with adult-onset schizophrenia (AOS, onset age ≥ 20) for the subsequent analyses. The age of schizophrenia onset was defined via consulting patients' family members and tracking the medical records. Patients with other major psychiatric disorders, severe neurological abnormalities, mental retardation, substance-related disorders, somatic disorders with neurological components, traumatic brain injuries, or prominent drug use problems were excluded from this study. The healthy controls with a personal or family history of psychiatric disorder were also excluded from the control group. This study's protocol, including its purpose, methods, and use of data collected, was approved by the institutional review board (IRB) of each participating hospital. All participants provided written informed consent to participate by signing the IRB-approved consent form.. heroin); 7) alters their personality and consequent ability to evaluate. 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Exposure to this metal is associated with large range of symptom [4,5]..